Transgenic Mouse Models and Human Neurodegenerative Disorders
نویسندگان
چکیده
منابع مشابه
Transgenic mouse models and human neurodegenerative disorders.
T he development of new methods for manipulating the mouse genome by transgenic and gene-targeting technologies has dramatically increased our ability to create mouse models for human genetic diseases. These mouse models have greatly facilitated the understanding of the pathogenesis of some human diseases and are beginning to be used in screening of therapeutic agents. In this review, we outlin...
متن کاملNeurodegenerative Tauopathies Human Disease and Transgenic Mouse Models
syndromes are characterized and increasing attention Prominent filamentous tau inclusions are increasingly is focused on the relationship of different FTDP-17 genorecognized as the hallmark neuropathology of a growing types to the heterogeneous phenotypic manifestations family of neurodegenerative diseases collectively known of these hereditary neurodegenerative tauopathies (Hong as tauopathies...
متن کاملMouse models of human neurodegenerative disorders: requirements for medication development.
Central nervous system diseases constitute a major target for drug development. Transgenic mouse models, in which genes identified in familial forms of human brain diseases are expressed in mouse neurons and glia, offer opportunities to detect and follow pathologic progression and provide potential biomarkers by which to assess therapeutic interventions. Evidence for Alzheimer disease suggests ...
متن کاملTransgenic Mouse Models and Human Psychiatric Disease
Genetic susceptibility to common psychiatric disease arises from the complex interactions between a multitude of genes and an unknown number of relevant environments. However, a common method for investigating gene function involves the creation of a mouse knockout of a candidate gene. Although this approach seems inappropriate to model such complexity, genetic effects on behavior attributable ...
متن کاملTransgenic mouse models of childhood-onset psychiatric disorders
Childhood onset psychiatric disorders, such as Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Mood Disorders, Obsessive Compulsive Spectrum Disorders (OCSD), and Schizophrenia (SZ), affect many school age children leading to a lower quality of life, including difficulties in school and personal relationships that persists into adulthood. Currently, the causes o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2000
ISSN: 0003-9942
DOI: 10.1001/archneur.57.12.1695